… in people without significant glycosylation defects, as long as … model of gluten-induced
experimental IgA glomerulopathy. … B cells are involved in nephritogenic IgA synthesis in a T-cell-…

… -deficient O-glycans in its hinge region (galactose-deficient IgA1… This scenario is further
supported by the results of experiments … that are responsible for promoting the migration of these …

… , but only after induction of a defective mucosal tolerance [24, … a gluten-induced experimental
IgA glomerulopathy. Moreover… antigens and breakdown of oral tolerance. In other studies, a …

… from IgAN patients are enriched with these galactose-deficient … demonstrated; both in vitro
and in vivo experiments have … Although the key feature of nephritogenic IgA in IgAN is that …

… with IgA nephropathy are enriched for galactose-deficient IgA1 … These experimental
approaches demonstrate the key roles … in the formation of nephritogenic immune complexes. …

… Moreover, nephritogenic IgA and its related immune … -specific IgA has been investigated
with some experimental models … in autoimmune states, inducing a defect in the regulation of B…

… The IgA in these renal deposits is galactose-deficient IgA1, … the formation and the nephritogenic
activities of these complexes. … short-term culture experiments of human tissues supported …

… in mice, with a defective mucosal tolerance, by intranasal … with the production of nephritogenic
IgA. NALT-activated B cells … , suggesting a gluten-induced experimental IgAN. Recently, in …

… carry immunological defects such as high IgA serum levels, … be validated by in vivo
experiments, they support the hypothesis … challenge that triggers the production of nephritogenic …

… These complexes are formed by galactose-deficient (Gd) IgA1 … To assess characteristics
of nephritogenic IgA and IgA-IC … of experimental IgAN following oral immunization with …